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1

Discovery of piperidine carboxamide TRPV1 antagonists

Wing S. Cheung, Raul R. Calvo, Brett A. Tounge, Sui-Po Zhang, Dennis R. Stone, Michael R. Brandt, Tasha Hutchinson, Christopher M. Flores, Mark R. Player

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 253 KB

english, 2008

2

The effect of chronic high insulin exposure upon metabolic and myogenic markers in C2C12 skeletal muscle cells and myotubes

Turner, Mark C, Player, Darren J, W Martin, Neil R., Akam, Elizabeth C, Lewis, Mark P

Journal:

Journal of Cellular Biochemistry

Year:

2018

Language:

english

File:

PDF, 705 KB

english, 2018

3

Functional regeneration of tissue engineered skeletal muscle in vitro is dependent on the inclusion of basement membrane proteins

Fleming, Jacob W., Capel, Andrew J., Rimington, Rowan P., Player, Darren J., Stolzing, Alexandra, Lewis, Mark P.

Journal:

Year:

2019

Language:

english

File:

PDF, 1.55 MB

english, 2019

4

ChemInform Abstract: 2-Methyladenosine-Substituted 2′,5′-Oligoadenylates: Conformations, 2-5A Binding and Catalytic Activities with Human Ribonuclease L.

Yukio Kitade, Masaharu Wakana, Takayuki Tsuboi, Chizuko Yatome, Suzanne F. Bayly, Mark R. Player, Paul F. Torrence

Journal:

Year:

2000

File:

PDF, 26 KB

2000

5

ChemInform Abstract: Replacement of the Phosphodiester Linkage in DNA with Sulfamide and 3′-N-Sulfamate Groups.

Kevin J. Fettes, Nigel Howard, David T. Hickman, Steven A. Adah, Mark R. Player, Paul F. Torrence, Jason Micklefield

Journal:

Year:

2000

File:

PDF, 30 KB

2000

6

ChemInform Abstract: Synthesis and Nucleic-Acid-Binding Properties of Sulfamide- and 3′-N-Sulfamate-Modified DNA.

Kevin J. Fettes, Nigel Howard, David T. Hickman, Steven Adah, Mark R. Player, Paul F. Torrence, Jason Micklefield

Journal:

Year:

2002

Language:

english

File:

PDF, 35 KB

english, 2002

7

Parallel Synthesis of Benzoxazoles via Microwave-Assisted Dielectric Heating.

Richard S. Pottorf, Naresh K. Chadha, Martins Katkevics, Vita Ozola, Edgars Suna, Hadi Ghane, Tor Regberg, Mark R. Player

Journal:

Year:

2003

File:

PDF, 104 KB

2003

8

Solution-Phase Synthesis of a Library of 3,5,7-Trisubstituted 3H-[1,2,3]triazolo[4,5-d]pyrimidines.

Nand Baindur, Naresh Chadha, Mark R. Player

Journal:

Year:

2004

File:

PDF, 119 KB

2004

9

Process Technologies for Purity Enhancement of Large Discovery Libraries

Richard S. Pottorf, Mark R. Player

Journal:

Year:

2005

File:

PDF, 8 KB

2005

10

A Tandem Heck-Carbocyclization/Suzuki-Coupling Approach to the Stereoselective Syntheses of Asymmetric 3,3-(Diarylmethylene)indolinones.

Wing S. Cheung, Raymond J. Patch, Mark R. Player

Journal:

Year:

2005

File:

PDF, 27 KB

2005

11

ChemInform Abstract: Developments in Factor Xa Inhibitors for the Treatment of Thromboembolic Disorders

Yu-Kai Lee, Mark R. Player

Journal:

Year:

2011

File:

PDF, 18 KB

2011

12

Developments in factor Xa inhibitors for the treatment of thromboembolic disorders

Yu-Kai Lee, Mark R. Player

Journal:

Medicinal Research Reviews

Year:

2011

Language:

english

File:

PDF, 2.35 MB

english, 2011

13

Structure-based design, synthesis, and biological evaluation of novel 1,4-diazepines as HDM2 antagonists

Pierre Raboisson, Juan José Marugán, Carsten Schubert, Holly K. Koblish, Tianbao Lu, Shuyuan Zhao, Mark R. Player, Anna C. Maroney, Rolanda L. Reed, Norman D. Huebert, Jennifer Lattanze, Daniel J. Par

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 163 KB

english, 2005

14

Enantiomerically pure 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists

Juan Jose Marugan, Kristi Leonard, Pierre Raboisson, Joan M. Gushue, Raul Calvo, Holly K. Koblish, Jennifer Lattanze, Shuyuan Zhao, Maxwell D. Cummings, Mark R. Player, Carsten Schubert, Anna C. Maron

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 229 KB

english, 2006

15

Novel 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists with improved cellular activity

Kristi Leonard, Juan Jose Marugan, Pierre Raboisson, Raul Calvo, Joan M. Gushue, Holly K. Koblish, Jennifer Lattanze, Shuyuan Zhao, Maxwell D. Cummings, Mark R. Player, Anna C. Maroney, Tianbao Lu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 153 KB

english, 2006

16

2-(2-Chloro-6-fluorophenyl)acetamides as potent thrombin inhibitors

Lily Lee, Kevin D. Kreutter, Wenxi Pan, Carl Crysler, John Spurlino, Mark R. Player, Bruce Tomczuk, Tianbao Lu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 208 KB

english, 2007

17

Potent 2′-aminoanilide inhibitors of cFMS as potential anti-inflammatory agents

Raymond J. Patch, Benjamin M. Brandt, Davoud Asgari, Nand Baindur, Naresh K. Chadha, Taxiarchis Georgiadis, Wing S. Cheung, Ioanna P. Petrounia, Robert R. Donatelli, Margery A. Chaikin, Mark R. Player

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 228 KB

english, 2007

18

Design and synthesis of a pyrido[2,3-d]pyrimidin-5-one class of anti-inflammatory FMS inhibitors

Hui Huang, Daniel A. Hutta, Huaping Hu, Renee L. DesJarlais, Carsten Schubert, Ioanna P. Petrounia, Margery A. Chaikin, Carl L. Manthey, Mark R. Player

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 466 KB

english, 2008

19

Solid-phase synthesis of 4-biaryl-piperidine-4-carboxamides

Jin Zhu, Richard S. Pottorf, Mark R. Player

Journal:

Tetrahedron Letters

Year:

2006

Language:

english

File:

PDF, 116 KB

english, 2006

20

A novel reagent combination for the oxidation of highly electron deficient pyridines to N-oxides: trifluoromethanesulfonic anhydride/sodium percarbonate

Xizhen Zhu, Kevin D. Kreutter, Huaping Hu, Mark R. Player, Micheal D. Gaul

Journal:

Tetrahedron Letters

Year:

2008

Language:

english

File:

PDF, 103 KB

english, 2008

21

Parallel synthesis of benzoxazoles via microwave-assisted dielectric heating

Richard S. Pottorf, Naresh K. Chadha, Martins Katkevics, Vita Ozola, Edgars Suna, Hadi Ghane, Tor Regberg, Mark R. Player

Journal:

Tetrahedron Letters

Year:

2003

Language:

english

File:

PDF, 263 KB

english, 2003

22

Transdermal and dermal enhancing activity of pyrrolidinones in hairless mouse skin

Donald A Godwin, Bozena B Michniak, Mark R Player, J Walter Sowell Sr

Journal:

International Journal of Pharmaceutics

Year:

1997

Language:

english

File:

PDF, 177 KB

english, 1997

23

Synthesis and investigation of urea compounds as transdermal penetration enhancers

Donald A. Godwin, Mark R. Player, J.Walter Sowell, Bozena B. Michniak

Journal:

International Journal of Pharmaceutics

Year:

1998

Language:

english

File:

PDF, 186 KB

english, 1998

24

1,3-Oxazino[4,5-b]indole-2,4-(1H,9H)-diones and 5,6-dimethylpyrrolo-[2,3-d]-1,3-oxazin-2,4-(1H,7H)-diones as serine protease inhibitors

Mark R. Player, J.Walter Sowell Sr., Girish S. Patil, Kam Chih-Min, James C. Powers

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 312 KB

english, 1994

25

Phosphorothioate oligodeoxyribonucleotides inhibit ribonuclease L thereby disabling a mechanism of interferon action

Mark R. Player, Paul F. Torrence

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 279 KB

english, 1999

26

Discrimination between ribonuclease H- and ribonuclease L-mediated RNA degradation by 2′-O-methylated 2-5A-antisense oligonucleotides

Hagen Cramer, Mark R. Player, Paul F. Torrence

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 378 KB

english, 1999

27

2-Methyladenosine-substituted 2′,5′-oligoadenylates: conformations, 2-5A binding and catalytic activities with human ribonuclease L

Yukio Kitade, Masaharu Wakana, Takayuki Tsuboi, Chizuko Yatome, Suzanne F Bayly, Mark R Player, Paul F Torrence

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 119 KB

english, 2000

28

2′,5′-Oligoadenylate-peptide nucleic acids (2–5A-PNAs) activate RNase L

Jeroen C Verheijen, Gijsbert A van der Marel, Jacques H van Boom, Suzanne F Bayly, Mark R Player, Paul F Torrence

Journal:

Bioorganic & Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 288 KB

english, 1999

29

Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3

Raymond J. Patch, Christian A. Baumann, Jian Liu, Alan C. Gibbs, Heidi Ott, Jennifer Lattanze, Mark R. Player

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 203 KB

english, 2006

30

Exploration of Potential Prodrugs of RWJ-445167, an Oxyguanidine-based Dual Inhibitor of Thrombin and Factor Xa

Bruce E. Maryanoff, David F. McComsey, Michael J. Costanzo, Stephen C. Yabut, Tianbao Lu, Mark R. Player, Edward C. Giardino, Bruce P. Damiano

Journal:

Chemical Biology & Drug Design

Year:

2006

Language:

english

File:

PDF, 533 KB

english, 2006

31

Synthesis and in vitro transdermal penetration enhancing activity of lactam N-acetic acid esters

Bozena B. Michniak, Mark R. Player, J. Walter Sowell, Sr.

Journal:

Journal of Pharmaceutical Sciences

Year:

1996

Language:

english

File:

PDF, 132 KB

english, 1996

32

In vitro evaluation of a series of N-dodecanoyl-L-amino acid methyl esters as dermal penetration enhancers

Timothy K. Fincher, Sun D. Yoo, Mark R. Player, J. Walter Sowell, Sr., , Bozena B. Michniak

Journal:

Journal of Pharmaceutical Sciences

Year:

1996

Language:

english

File:

PDF, 145 KB

english, 1996

33

Preparation of fused 1,3-oxazine-2,4-diones as potential antitumor agents

Mark R. Player, J. Walter Sowell Sr.

Journal:

Journal of Heterocyclic Chemistry

Year:

1995

File:

PDF, 316 KB

1995

34

Synthesis of 1,3-disubstituted-5-oxo-7a-methyl-5,7a-dihydroindoles

Mark R. Player, Li-Chang Wang, Said M. Bayomi, J. Walter Sowell Sr.

Journal:

Journal of Heterocyclic Chemistry

Year:

1992

File:

PDF, 254 KB

1992

35

Synthesis of 1,3-disubstituted-2-amino-5-hydroxyindoles by reductive aromatization

Mark R. Player, J. Walter Sowell Sr.

Journal:

Journal of Heterocyclic Chemistry

Year:

1993

File:

PDF, 265 KB

1993

36

Synthesis of 2,7-disubstituted-5,6-dimethylpyrrolo-[2,3-d]-1,3-oxazin-4-ones as antifungal agents

Mark R. Player, J. Walter Sowell Sr., Glenn R. Williams, Gerald T. Cowley

Journal:

Journal of Heterocyclic Chemistry

Year:

1994

File:

PDF, 427 KB

1994

37

Competing Impact of Excess Weight Versus Cardiorespiratory Fitness on Cardiovascular Risk

Vanessa A. Diaz, Marty S. Player, Arch G. Mainous III, Peter J. Carek, Mark E. Geesey

Journal:

The American Journal of Cardiology

Year:

2006

Language:

english

File:

PDF, 306 KB

english, 2006

38

Discovery of vinylcycloalkyl-substituted benzimidazole TRPM8 antagonists effective in the treatment of cold allodynia

Raul R. Calvo, Sanath K. Meegalla, Daniel J. Parks, William H. Parsons, Shelley K. Ballentine, Mary Lou Lubin, Craig Schneider, Raymond W. Colburn, Christopher M. Flores, Mark R. Player

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 2.10 MB

english, 2012

39

The 2–5 A system: Modulation of viral and cellular processes through acceleration of RNA degradation

Mark R. Player, Paul F. Torrence

Journal:

Pharmacology & Therapeutics

Year:

1998

Language:

english

File:

PDF, 7.72 MB

english, 1998

40

Solid-Phase Synthesis of an Oxalic Acid Amide Library

Georgiadis, Taxiarchis M., Baindur, Nand, Player, Mark R.

Journal:

Journal of Combinatorial Chemistry

Year:

2004

Language:

english

File:

PDF, 54 KB

english, 2004

41

Dissection of the Roles of Adenine Ring Nitrogen (N-1) and Exocyclic Amino (N-6) Moieties in the Interaction of 2-5A with RNase L

Mark R. Player, Elena N. Kalinichenko, Tatjana L. Podkopaeva, Igor A. Mikhailopulo, Frank Seela, Paul F. Torrence

Journal:

Biochemical and Biophysical Research Communications

Year:

1998

Language:

english

File:

PDF, 537 KB

english, 1998

42

Ribonuclease L, a 2-5A-Dependent Enzyme: Purification to Homogeneity and Assays for 2-5A Binding and Catalytic Activity

Mark R. Player, Ewald M. Wondrak, Suzanne F. Bayly, Paul F. Torrence

Journal:

Year:

1998

Language:

english

File:

PDF, 655 KB

english, 1998

43

Use of Statins and Blood Pressure

Dana E. King, Arch G. Mainous III, Brent M. Egan, Marty Player, Mark E. Geesey

Journal:

American Journal of Hypertension

Year:

2007

Language:

english

File:

PDF, 81 KB

english, 2007

44

Target-based compound library design and synthesis

Journal:

Drug Discovery Today: TARGETS

Year:

2004

Language:

english

File:

PDF, 130 KB

english, 2004

45

Modelling in vivo skeletal muscle ageing in vitro using three-dimensional bioengineered constructs

Adam P. Sharples, Darren J. Player, Neil R. W. Martin, Vivek Mudera, Claire E. Stewart, Mark P. Lewis

Journal:

Year:

2012

Language:

english

File:

PDF, 549 KB

english, 2012

46

Solid-Phase Synthesis of a Library of Hydroxyproline Derivatives

Vergnon, Anne L., Pottorf, Richard S., Player, Mark R.

Journal:

Journal of Combinatorial Chemistry

Year:

2004

Language:

english

File:

PDF, 137 KB

english, 2004

47

Small-molecule inhibitors of the p53-HDM2 interaction for the treatment of cancer

Patel, Sharmila, Player, Mark R

Journal:

Expert Opinion on Investigational Drugs

Year:

2008

Language:

english

File:

PDF, 866 KB

english, 2008

48

Nuclease-Resistant Composite 2‘,5‘-Oligoadenylate−3‘,5‘-Oligonucleotides for the Targeted Destruction of RNA: 2−5A-Iso-antisense

Xiao, Wei, Li, Guiying, Player, Mark R., Maitra, Ratan K., Waller, Cornelius F., Silverman, Robert H., Torrence, Paul F.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 104 KB

english, 1998

49

Single-Step Syntheses of 2-Amino-7-chlorothiazolo[5,4- d ]pyrimidines: Intermediates for Bivalent Thiazolopyrimidines

Liu, Jian, Patch, Raymond J., Schubert, Carsten, Player, Mark R.

Journal:

Journal of Organic Chemistry

Year:

2005

Language:

english

File:

PDF, 187 KB

english, 2005

50

Factors affecting the structure and maturation of human tissue engineered skeletal muscle

Martin, Neil R.W., Passey, Samantha L., Player, Darren J., Khodabukus, Alastair, Ferguson, Richard A., Sharples, Adam P., Mudera, Vivek, Baar, Keith, Lewis, Mark P.

Journal:

Year:

2013

Language:

english

File:

PDF, 2.16 MB

english, 2013

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